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Fmoc-8-amino-3,6-dioxaoctanoic acid
Fmoc-8-amino-3,6-dioxaoctanoic acid
CAS No. 166108-71-0
Fmoc-8-amino-3,6-dioxaoctanoic acid( Fmoc-NH-PEG2-CH2COOH )
Catalog No. M23745 CAS No. 166108-71-0
Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1G | 29 | In Stock |
|
Biological Information
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Product NameFmoc-8-amino-3,6-dioxaoctanoic acid
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NoteResearch use only, not for human use.
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Brief DescriptionFmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DescriptionFmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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In VitroADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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SynonymsFmoc-NH-PEG2-CH2COOH
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PathwayAntibody Drug Conjugates (ADC)
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TargetADCs Linker/Click Chemistry
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RecptorADC Linker|PROTAC Linker
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Research Area——
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Indication——
Chemical Information
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CAS Number166108-71-0
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Formula Weight385.41
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Molecular FormulaC21H23NO6
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESO=C(O)COCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nakamura A, et al. Chemogenetic Control of Protein Anchoring to Endomembranes in Living Cells with Lipid-Tethered Small Molecules. Biochemistry. 2020 Jan 21;59(2):205-211.
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